Beyond the exome

DFG funded Research Group

People of Beyond the exome

PhD Mina Gouti

Testbeschreibung Stem Cell Modeling of Development and Disease Lab
Max Delbrück Center
Robert Rossler Strasse 10
13125 Berlin, Germany

Phone: +49 (0)30 94062610
picture Copyright © Pablo Castagnola

Mina Gouti, is a group leader at the Max Delbrück Center for Molecular Medicine in Berlin and an EMBO Young Investigator. She is a Principal Investigator at the Einstein Center for 3R (EC3R) and the Einstein Center for Neurosciences in Berlin. She also serves on the Strategy Board and the Pluripotent Stem Cell and Organoid Platform Committee at MDC, as well as on the Extended Board of the German Stem Cell Network. She received an M.Sc. in Molecular Medicine from Imperial College London. During her Ph.D. and Postdoctoral studies, she trained with Prof. Anthony Gavalas (BRFAA, Athens) and Prof. James Briscoe (Francis Crick Institute, London) in Stem Cells and Developmental Biology. She has received several recognitions and awards including an ERC consolidator grant (GPSorganoids) in 2020 and an ERC Proof of Concept grant (mini-organs) in 2022. Her lab uses human pluripotent stem cells to build advanced 2D and 3D organoid models to study the development and disease of the neuromuscular system. The Gouti lab has achieved a milestone in creating human 3D neuromuscular organoids (NMOs) from in vitro-derived neuromesodermal progenitors, demonstrating self-organization into distinct spinal cord neural and skeletal muscle compartments. These NMOs offer unprecedented opportunities to study human developmental events and analyze the contributions of different cell types to neuromuscular disorders. Leveraging gain and loss of gene function approaches, next-generation sequencing technologies, and live cell imaging, her lab is actively investigating spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), muscular dystrophies (MD), and other neuromuscular conditions. The Gouti lab is dedicated to unraveling the fundamental mechanisms driving both normal development and pathological conditions of the neuromuscular system, aiming to pave the way for novel drug therapies.

Publications (selection)

Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells. Nature Communications 2023 Dec 19; Alessia Urzi, Ines Lahmann, Lan Vi N. Nguyen, Benjamin R. Rost, Angélica García-Pérez, Noemie Lelievre, Megan E. Merritt-Garza, Han C. Phan, Gary J. Bassell, Wilfried Rossoll, Sebastian Diecke, Severine Kunz, Dietmar Schmitz, Mina Gouti

Self-Organizing 3D Human Trunk Neuromuscular Organoids. Cell Stem Cell. 2020 Feb 6;26(2):172-186.e6. doi: 10.1016/j.stem.2019.12.007. Faustino Martins JM, Fischer C, Urzi A, Vidal R, Kunz S, Ruffault PL, Kabuss L, Hube I, Gazzerro E, Birchmeier C, Spuler S, Sauer S, Gouti M.

Nervous System Regionalization Entails Axial Allocation before Neural Differentiation. Cell. 2018 Nov 1;175(4):1105-1118.e17. doi: 10.1016/j.cell.2018.09.040. Epub 2018 Oct 18. Metzis V, Steinhauser S, Pakanavicius E, Gouti M, Stamataki D, Ivanovitch K, Watson T, Rayon T, Mousavy Gharavy SN, Lovell-Badge R, Luscombe NM, Briscoe J

A Gene Regulatory Network Balances Neural and Mesoderm Specification during Vertebrate Trunk Development. Dev Cell. 2017 May 8; 41:1–19. Gouti M*, Delile J, Stamataki D, Wymeersch F. J, Huang Y, Kleinjung J, Wilson V, Briscoe J*.

In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity. PLoS Biol. 2014 Aug 26;12(8). Gouti M*, Tsakiridis A, Wymeersch FJ, Huang Y, Kleinjung J, Wilson V, Briscoe J*.